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Integrative Microbiomics In Bronchiectasis Exacerbations

Di: Jacob

Schlagwörter:Bronchiectasis ExacerbationsPublished:2023/12/12

Integrative microbiomics in bronchiectasis exacerbations

Integrative microbiomics captures microbial interactions to determine exacerbation risk, which cannot be appreciated by the study of a single microbial.Schlagwörter:Microbiology in BronchiectasisBronchiectasis Airways We applied WSNF to evaluate the bronchiectasis microbiome and assessed respiratory specimens that captured bacterial, fungal, and viral taxa from 217 patients.Bronchiectasis, a progressive chronic airway disease, is characterized by microbial colonization and infection. Integrative microbiomics in bronchiectasis exacerbations.Pseudomonas and Haemophilus-dominated microbiomes have been linked to more severe diseases and frequent exacerbations, however additional research is required to fully comprehend the role of microbiome in the evolution of bronchiectasis. Google Scholar; Here, we review our current . Micheál Mac Aogáin, Jayanth Kumar Narayana, Pei Yee Tiew, Nur A’tikah Binte Mohamed Ali, Valerie Fei Lee Yong, Tavleen Kaur Jaggi, Albert Yick Hou Lim, Holly R.Chronic obstructive pulmonary disease (COPD) is a worldwide health challenge, ranking third leading cause of death globally [].3 The influence of airway . A UK study evaluating the impact of 14 days of intravenous antibiotics showed .To further assess this, our group recently performed the first integrative microbiomics study, which combined concurrent assessment of bacteria, fungi, and viral communities in bronchiectasis . Traditional culture-based, .Abstract: Bronchiectasis, a progressive chronic airway disease, is characterized by microbial colonization and infection. Patients at greatest risk .

Prevention of exacerbations in stable patients with bronchiectasis ...

Schlagwörter:Bronchiectasis ExacerbationsIntegrative MicrobiomicsPublish Year:2021

Integrative microbiomics in bronchiectasis exacerbations

Although specific pathogens are implicated in bronchiectasis exacerbations, prior bacterial microbiome studies show minimal actual change during exacerbations-based analyses ofSchlagwörter:Bronchiectasis ExacerbationsIntegrative MicrobiomicsScience::Medicine

Integrative microbiomics in bronchiectasis exacerbations

Microbiology and infection are central tenants in the pathogenesis and progression of bronchiectasis.

(PDF) Dynamic Upper and Lower Airway Microbiotas in Paediatric ...

This study used metagenomic next-generation sequencing (mNGS) technology to explore the changes of the microbial characteristics in the lower respiratory . Nature Medicine. The microbiome in . Dicker, Kai Xian Thng, Akina Tsang, Fransiskus Xaverius Ivan, Mau Ern Poh, Martina Oriano, Stefano . Dicker, Heather Barclay, James D.Bronchiectasis is a chronic airway disease that is characterized by progressive and irreversible dilatation of bronchus due to the recurrent damage of the ./results/*_matrix.Integrative microbiomics in bronchiectasis exacerbationsExacerbations of Bronchiectasis, Prevention and Treatment. 2021; Nat Med; PMID 33820995; DOI 10.Patients with bronchiectasis present with cough and recurrent respiratory infections and experi-ence pulmonary exacerbations necessitating anti-microbial therapy including hospitalization.This code uses Similarity Network Fusion(SNF) to merge 2 microbiomes and clusters the integrated biome using spectral clustering. AU Mac Aogáin M, Narayana JK, Tiew PY, Ali NABM, Yong VFL, Jaggi TK, Lim AYH, Keir HR, Dicker AJ, Thng KX, Tsang A, Ivan FX, Poh ME, Oriano M, Aliberti S, Blasi F, Low TB, Ong TH, Oliver B, Giam YH, Tee A, Koh MS, Abisheganaden JA, Tsaneva-Atanasova K, Chalmers JD, . The results of the analysis, i.The microbiome has not been extensively studied in bronchiectasis, but existing data show lung bacterial communities dominated by Pseudomonas, Haemophilus and .Singapore Ministry of Health National Medical Research CouncilBronchiectasis is increasing in prevalence worldwide, yet current treatments available are limited to those alleviating symptoms and reducing exacerbations.Results: “Integrative microbiomics” identifies patients at high-risk of exacerbation.Bacterial, viral and fungal communities in bronchiectasis have been found to be associated with clinical outcomes, includ-ing exacerbations7–9. Bronchiectasis, a progressive chronic airway disease, is characterized by microbial colonization and infection.A multiomics approach integrating clinical parameters with the bacteriome, virome, transcriptome, and metabolome in infants with respiratory syncytial virus identifies endotypes relating to risk of subsequent childhood asthma, while in bronchiectasis, multibiome (bacteria, viruses, and fungi) integration resolves a “high-risk” group .We present an approach to the multi-biome that integrates bacterial, viral and fungal communities in bronchiectasis through weighted similarity network fusion . Micheál Mac Aogáin, Jayanth Kumar Narayana, Pei Yee Tiew, Nur A’tikah Binte Mohamed Ali, Valerie Fei Lee . Google Scholar, 8. 2021; 27: 688-699. The pathogenesis of the disease and the inflammatory, infective and molecular drivers of disease progression are not fully understood, making t .1038/s41591-021-01289-7; Bronchiectasis, a progressive chronic airway disease, is characterized by microbial colonization and infection. Although central to our current understanding of disease, microbial culture alone masks the holistic complexity of the .Ministry of Health (MOH)Schlagwörter:Bronchiectasis ExacerbationsIntegrative MicrobiomicsIncreasing evidence suggest that airway dysbiosis . We present an approach to the multi-biome that integrates bacterial, viral and fungal communities in bronchiectasis through weighted similarity.

UpToDate

Our integrative microbiomics pipeline is available as a web tool.

Lung microbiome: new insights into bronchiectasis’ outcome

001) and severe exacerbations (OR, 1. We present an approach to We present an approach to the multi-biome that integrates bacterial, viral and fungal communities in bronchiectasis through weighted similarity network fusion ( https://integrative-microbiomics.It is featured by persistent airway inflammation, emphysema, and airflow obstruction, with episodes of exacerbations accelerating disease progress []. Micheál Mac Aogáin J. Exacerbations are major cause of morbidity and mortality in bronchiectasis and .Schlagwörter:Bronchiectasis ExacerbationsIntegrative Microbiomics Medicine, Environmental Science.The microbiology in bronchiectasis has been historically defined by culture-based analysis of the airway microbiome and to date has largely focused on the .Integrative microbiomics.Schlagwörter:Bronchiectasis ExacerbationInteractome It was also highlighted that inclusion of microbial interaction data can improve the performance of bronchiectasis exacerbation prediction models (Mac . This review discusses recent findings on the lung microbiota and its association with bronchiectasis.In a UK study including 385 patients with bronchiectasis, there was a direct relationship between bacterial load and the risk of subsequent exacerbations (OR, 1. Frequent exacerbators exhibit reduced α-diversity and elevated antagonistic interactions.Using a combination of human cohorts, next-generation sequencing, systems biology, and animal models, we show that bronchiectasis bacteriomes defined .

Causes of bronchiectasis exacerbations. | Download Scientific Diagram

The microbiology in bronchiectasis has been historically defined by culture-based analysis of the airway microbiome and to date has largely focused on the detection and eradication of specific bacterial pathogens. Keir, Alison J. We present an approach to the .Integrative microbiomics in bronchiectasis exacerbations. Metagenomics reveals a core macrolide resistome related to microbiota in chronic respiratory disease. Although specific . Patients at greatest risk of ./results/*_labels. Integrative microbiomics in . the cluster labels and similarity matrices are written into the results directory as . Narayana +23 authors S. Rather than changes in individual single-kingdom microbiomes, a significant change in the microbial interactions (or the “interactome”) in .It is suggested that metagenomic next-generation sequencing (mNGS) could be used to identify pathogenic microorganisms in patients with acute exacerbations .

Integrative Microbiomics: Analytical Approaches to Respiratory Microbiota

1–3 The chronic, irreversible dilatation of the bronchi observed in bronchiectasis has been linked to elastin degradation and the loss of supportive tis- OPUS at UTS; Faculty of Science; School of Life Sciences

Microbiology and the Microbiome in Bronchiectasis - Clinics in Chest ...

Schlagwörter:Hollian Richardson, Alison J.

Integrative microbiomics in bronchiectasis exacerbations | Nature Medicine

(2021) Mac Aogáin et al.Mac Aogáin, M.We present an approach to the multi-biome that integrates bacterial, viral and fungal communities in bronchiectasis through weighted similarity network fusion ( .Data on the use of “integrative microbiomics” in bronchiectasis demonstrate a specific Pseudomonas interactome in the prediction of exacerbation risk.Schlagwörter:Bronchiectasis ExacerbationsIntegrative MicrobiomicsAugustine Tee We present an approach to the multi-biome that integrates bacterial, viral and fungal communities in bronchiectasis through weighted similarity network fusion (https://integrative-microbiomics.Integrative microbiome data analysis indicated that both the abundance and the interaction network of Pseudomonas spp. Bronchiectasis, a progressive chronic airway disease, is characterized by microbial colonization and .

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Crossref; PubMed; . 2021; Bronchiectasis, a progressive chronic airway disease, is characterized by microbial colonization and infection. Am J Respir Crit Care Med. Spectral clustering of the resultant similarity network identified two patient clusters that we mapped onto clinical .Integrative microbiomics in bronchiectasis exacerbations; Mac Aogáin M, Narayana JK, Tiew PY, et al.Ministry of Health (MOH)“integrative microbiomics” in bronchiectasis demonstrate a specific Pseudomonas interactome in the prediction of exacerbation risk.Schlagwörter:Assessment of The PseudomonasMicrobiome Interagency Working Group

Integrative microbiomics in bronchiectasis exacerbations

Schlagwörter:Integrative MicrobiomicsMicrobiology in Bronchiectasiscsv where * represents bacteria+fungi, fungi+virus.Schlagwörter:Bronchiectasis ExacerbationInteractome

Changes in the airway microbiome in patients with bronchiectasis

are associated with exacerbations in bronchiectasis.We demonstrate that integrative microbiomics pro- occurrence and frequency in bronchiectasis and other respiratory vides a novel framework for understanding .Schlagwörter:Bronchiectasis ExacerbationsIntegrative MicrobiomicsPublish Year:2021 2020; 202: 433-447.Schlagwörter:Bronchiectasis ExacerbationsIntegrative Microbiomics